Cryptosporidium parvum infection requires host cell actin polymerization.

نویسندگان

  • D A Elliott
  • D J Coleman
  • M A Lane
  • R C May
  • L M Machesky
  • D P Clark
چکیده

The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

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عنوان ژورنال:
  • Infection and immunity

دوره 69 9  شماره 

صفحات  -

تاریخ انتشار 2001